The Adam laboratory studies pathophysiology of the urinary and gastrointestinal tracts, with a primary focus on cell biology and signal transduction. Our overarching focus is on deciphering the molecular events that regulate growth, differentiation and pathologic remodeling in the urinary tract following discrete insults or injury, with the ultimate goal of identifying novel strategies for intervention. We also have a longstanding interest and publication history in bladder and prostate cancer and mechanisms of tumor progression. We use genetically engineered mice, in vivo models of disease and a variety of cell and molecular biology approaches to accomplish our goals.
Specific areas of study include:
- Network analysis of bladder wall remodeling following obstruction
- Neuropilin 2-mediated regulation of smooth muscle contraction and relaxation
- Neurogenic bladder evolution and treatment following spinal cord injury
- sRegulation of receptor tyrosine kinase signaling in bladder cancer progression
