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Dev

Research Overview

Dr. Ronald Mathieu primarily focuses on improving the flow cytometry research at the institution. He has worked with more than a thousand researchers since established the lab in 2008 on how to implement flow cytometry into their research. His teaching on fundamental flow cytometry, experiment design and data interpretation goes across institution. His passion for making sure every experiment works is the secret to his success. While his research interest focuses on understand the trick that cancer play on the innate immune system, he has work and collaborate with researcher from every department.

Research Background

Dr. Mathieu is a laboratory scientist at Boston Children’s Hospital and the director of the BCH-HSCI flow cytometry Facility. Before joining BCH, Dr. Mathieu was a flow cytometry application specialist at MIT, a Clinical Immunology scientist at Repromed and Medical Laboratory technician at North Medical Center.

Selected Publications

  1. Rowe RG, Lummertz da Rocha E, Sousa P, Mathieu R, et al. The developmental stage of the hematopoietic niche regulates lineage in MLL-rearranged leukemia. J Exp Med. 2019;216(3):527–538. doi:10.1084/jem.20181765
  2. Rowe RG, Wang LD, Coma S, Mathieu R, et al. Developmental regulation of myeloerythroid progenitor function by the Lin28b-let-7-Hmga2 axis. J Exp Med. 2016;213(8):1497–1512. doi:10.1084/jem.20151912
  3. Henderson LA, Volpi S, Frugoni F, Mathieu R, et al. Next-Generation Sequencing Reveals Restriction and Clonotypic Expansion of Treg Cells in Juvenile Idiopathic Arthritis. Arthritis Rheumatol. 2016;68(7):1758–1768. doi:10.1002/art.39606
  4. Ciuculescu MF, Park SY, Canty K, Mathieu R, Silberstein LE, Williams DA. Perivascular deletion of murine Rac reverses the ratio of marrow arterioles and sinusoid vessels and alters hematopoiesis in vivo. Blood. 2015;125(20):3105–3113. doi:10.1182/blood-2014-10-604892
  5. Dorrance AM, De Vita S, Radu M, Mathieu R, et al. The Rac GTPase effector p21-activated kinase is essential for hematopoietic stem/progenitor cell migration and engraftment. Blood. 2013;121(13):2474–2482. doi:10.1182/blood-2012-10-460709
  6. Henderson, Lauren & Volpi, Stefano & Frugoni, Francesco & Kim, Susan & Janssen, Erin & Sundel, Robert & Dedeoglu, Fatma & Lo, Mindy & Hazen, Melissa & Mathieu, Ronald & Fuhlbrigge, Robert & Lee, Yu Nee & Nigrovic, Peter & Notarangelo, Luigi. (2014). A119: Deep Sequencing Analysis of the T Regulatory and T Effector Repertoire in Juvenile Idiopathic Arthritis. Arthritis & Rheumatology. 66. 10.1002/art.38540.
  7. De Los Angeles, A., Ferrari, F., Fujiwara, Y, Mathieu R, et al. Failure to replicate the STAP cell phenomenon. Nature 525, E6–E9 (2015) doi:10.1038/nature15513