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Research Overview

Dr. Arnett and her research team aim to improve precision medicine care for children and families affected by neurodevelopmental disorders. Dr. Arnett’s laboratory investigates brain-behavior associations leading to atypical neurodevelopment among children. Research initiatives have included investigations of neurocognitive and genetic etiologies of ADHD, learning disorders and autism; as well as single gene disorders associated with autism and intellectual disability.

Research Background

Anne B. Arnett, PhD, is a Scientist in the Division of Developmental Medicine at Boston Children’s Hospital and a Wade Family Investigator in Child Psychology. She received a PhD in Clinical Psychology from the University of Denver and completed postdoctoral training at the University of Washington. Dr. Arnett’s research within the Laboratories of Cognitive Neuroscience at Boston Children’s Hospital utilizes electroencephalography (EEG), event-related potential (ERP) and neuropsychological methods to investigate individual variability among children at risk for attention deficit hyperactivity disorder (ADHD) and associated diagnoses. Dr. Arnett’s goal is to improve clinical care for children and families affected by ADHD and related neurodevelopmental disorders through identification of biomarkers that can inform precision medicine care practices.

Selected Publications

  1. Mamiya, P.a, Arnett, A.B.a, Stein, M.A. (2021). Precision Medicine Care in ADHD: The Case for Neural Excitation and Inhibition. Brain Sciences, 11(1), 91.
  2. Arnett, A.B., Beighley, J., Nelson, E., Hoekzema, K., Wang, T., Eichler, E.E. & Bernier, R.A. (2020). Developmental Predictors of Cognitive and Adaptive Outcomes in Genetic Subtypes of Autism Spectrum Disorder. Journal of Autism Research, 13(10), 1659-1669.
  3. Bren, M. S., Garg, P., Tang, L., Mendonca, D., Levy, T., Barbosa, M., Arnett, A. B., Kurtz-Nelson, E….Buxbaum, J.D., Siper, P.M., De Rubeis, S. (2020). Episignatures stratifying Helsmoortel-Van Der Aa Syndrome show modest correlation with phenotype. The American Journal of Human Genetics, 107(3), 555- 563.
  4. Trinh, S.a, Arnett, A.B.a, Kurtz-Nelson, E., Beighley, J., Picoto, M. & Bernier, R. (2020). Transcriptional Subtyping Explains Phenotypic Variability in Genetic Subtypes of Autism Spectrum Disorder. Development and Psychopathology, 1-9.
  5. Rutter, T.* & Arnett, A.B. (2020). Temperament Traits Mark Liability for Coexisting Psychiatric Symptoms in Children with Elevated ADHD Symptoms. Journal of Attention Disorders. 1087054720943282
  6. Beighley, J.S., Hudac, C., Arnett, A.B., Peterson, J.L., Gerdts, J., Wallace, A.S., Mefford, H., O’Roak, B.J., Eichler, E. & Bernier, R.A. (2020). Clinical phenotypes of carriers of mutations in CHD8 or its conserved target genes. Biological Psychiatry, 87(2), 123-131. https://doi.org/10.1016/j.biopsych.2019.07.020
  7. Arnett, A.B., Trinh, S., Bernier, R.A. (2019). The state of research on the genetics of autism spectrum disorder: methodological, clinical and conceptual progress. Current Opinion in Psychology, 27, 1-5.
  8. Arnett, A.B., Hudac, C., DesChamps, T., Cairney, B.E.*, Gerdts, J., Wallace, A.S., Bernier, R.A. & Webb, S.J. (2018). Auditory perception is associated with implicit language learning and receptive language ability in autism spectrum disorder. Brain and Language, 187, 1-8.
  9. Arnett, A.B. & Stein, M. (2018). Refining ADHD Treatment Choices: Invited Commentary. The Lancet Psychiatry, 5. doi: 10.1016/S2215-0366(18)30295-5.
  10. Arnett, A.B., Rhoads, C.L.*, Hoekzema, K., Turner, T.N., Gerdts, J., Wallace, A.S., Bedroisan-Sermone, S., Eichler, E.E. and Bernier, R.A. (2018). The autism spectrum phenotype in ADNP Syndrome. Journal of Autism Research, 11(9), 1300-1310.

Publications