Principal investigator
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Frederick Alt, PhD |
Assistant Professor
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Ming Tian, PhD Harvard University I generate mouse models to test HIV-1 vaccine candidates. The goal of HIV-1 vaccine development is to design immunization methods that can elicit broadly neutralizing antibodies against diverse viral strains. Our mouse models express precursors of broadly neutralizing antibodies. Immunization of these mouse models can evaluate the ability of the vaccine candidate to mature the precursor antibody into broadly neutralizing antibodies. |
Instructors
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Hongli Hu, PhD University of Chinese Academy of Sciences My current research is focus on cohesion unloader Wapl's function in V(D)J recombination.
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Zhuoyi Liang, PhD Hong Kong University of Science and Technology I am interested in DNA repair, recurrent DBS cluster (RDC) mapping and neural blastocyst complementation (NBC). |
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Yongxin Ye, PhD I work as a postdoctoral researcher, doing bioinformatic analysis, biostatistics testing and modeling for V(D)J recombination, somatic hypermutation and class switching recombination during B cell development, mainly based on high-throughput genome-wide translocation sequencing (HTGTS) and repertoire sequencing data. |
Postdoctoral Fellows
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Himanshu Batra I am interested in generating mouse models for obtaining novel broadly neutralizing antibodies to COVID-19 and HIV. In addition to that, I am studying the regulatory mechanisms of immunoglobulin light chain isotypic exclusion in B cells.
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Changbin Jing My research is focused on antibody class Switch recombination (CSR) and somatic hypermutation (SHM). I explore loop extrusion in SHM by deleting 3’RR enhancer or inserting CBE between 3’RR and V region. |
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Xiang Li My research is focused on the mechanism of V(D)J recombination and IgH allelic exclusion in developing B cells |
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Chengxian Xu My study is going to reveal the mechanisms of V(D)J recombination during B cell development. File upload |
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Zhuo Yang My research is focused on elucidating the mechanism of chromatin loop extrusion-mediated class switch recombination. |
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Lijuan Zhao, PhD University of Chinese Academic Science I have been using mouse modeling and high through put methods to elucidate the potentially complementary roles of the IgH locus intronic enhancer and the downstream IgH 3’ regulatory region enhancers in promoting V(D)J recombination and IgH variable region somatic hyper-mutation. |
Graduate Students
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Aseda Tena PhD student in Biological and Biomedical Sciences (BBS), Harvard University. I am interested in identifying mechanisms in brain neural progenitor cells that contribute to recurrent DNA breaks in a set of genes implicated in neuropsychiatric diseases and cancer.
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Yiwen Zhang PhD student in Biological and Biomedical Sciences (BBS), Harvard University I am interested in studying the regulatory mechanisms of chromatin 3D structure in the context of IgH V(D)J recombination in progenitor B cells. |
Staff
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Hwei-Ling Cheng Lab Manager/Research Specialist III |
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Kristen (Elyse) Gaertner Research Assistant I |
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Kerstin Johnson Research Assistant II |
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Xin Lin Bioinformatic Research Assistant II |
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Judy Needham Administrative Assistant
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Lucas Vieira Francisco Research Assistant II |
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Aimee Williams Lead Research Technologist
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