Ganglioglioma

Since gangliogliomas grow relatively slowly, a child may have been having symptoms for many months prior to diagnosis, or symptoms may appear more suddenly. Many children with gangliogliomas first present with seizures. Other symptoms are associated with increased pressure in the brain, including:

• headache: generally upon awakening in the morning
• nausea and vomiting: often worse in the morning and improving throughout the day
• fatigue
• weakness on one side of the body

Ganglioglioma symptoms may resemble those of other conditions or medical problems. Always consult your child's physician for a diagnosis.

A physician may order a number of different tests to best diagnose the tumor. In addition to a physical exam, medical history and neurological exam (which tests reflexes, muscle strength, eye and mouth movement, coordination and alertness), those tests may include:

• physical examination
• computerized tomography scan (also called a CT or CAT scan)
• magnetic resonance imaging (MRI)
• electroencephalogram (EEG)
• biopsy

After all tests are completed, doctors will be able to outline the best treatment options.

A child’s physician will determine a specific course of ganglioglioma treatment based on several factors. Some therapies will treat the tumor while others are intended to address complications of the disease or side effects of the treatment. Ganglioglioma treatments include:

• neurosurgery
• chemotherapy
• radiation therapy

Specific ganglioglioma treatments will be determined by your child's physician based on:

• your child's age, overall health, and medical history
• type, location, and size of the tumor
• extent of the disease
• your child's tolerance for specific medications, procedures, or therapies
• how your child's doctors expects the disease to progress
• your opinion and preference

The recommended treatment for progressive or recurrent ganglioglioma is radiation therapy. Clinical trials and experimental therapies are also available for children with recurrent tumors that are not responsive to standard therapies.

Children and adolescents with ganglioglioma are treated at Dana-Farber/Boston Children's Cancer and Blood Disorders Center through the Brain Tumor Center, one of the largest and most experienced pediatric brain tumor treatment programs in the world. Our brain tumor specialists have extensive expertise in treating all types of brain tumors, including ganglioglioma. Our patients receive care from neuro-oncologists, neurosurgeons, neurologists, and pediatric subspecialists.